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Biophysics Precedes Biochemistry In Hox Gene Collinearity

Submited on: 29 Apr 2014 09:15:50 AM GMT
Published on: 02 Aug 2014 05:17:41 AM GMT

Thank you for the invitation to review the manuscript

The manuscript represents a very interesting topic particularly if authors present a reliable way to prove their purpose.

It is appropriately written and includes appropriate references. However, there is insufficient scientific proof for the proposed subject. The authors are mostly discussing hypothesis through models & equations still that is how scientific ideas always begin.

 1. The manuscript should be checked for minor linguistic errors.

2.  Abbreviations in the manuscript need to be defined at their first occurrence.

I think the content is good and will be of interest to the readership of journal.

but please resubmit with appropriate spelling and grammar changes.

 
Posted by Prof. Ghada Y El-Kamah on 23 Jun 2014 05:51:04 PM GMT

Hox genes are genes that control the body developmental patterning along the anterior-posterior axis. In vertebrates, the Hox genes are grouped or clustered very close one another along the chromosome.  More interestingly the expression order of the gene is the same as the developing order of the embryo. However, the reason for this colinearity is not yet completely understood.  In this manuscript the authors proposed a new biophysical model instead of canonic “two-waves” model.  This new model is very interesting and gives us new insight into another angle of Hox gene regulation. By using this model, the authors can explain a lot findings especially the experiment of implanting signaling moleculars.  I just have two minor suggestion for this manuscript.

 

  1. Firstly the authors can draw a cartoon of  “two-waves” model side by side with “pulling force” model, which might help the readers easily distinguishing the difference between these two model.
  2. When the authors proposed this model, they did not count the force of histones. DNAs are not stay alone in some territory.  They tangled with histones and form chromatins.  So when the morphogen pulling them out, it is not simply pulling DNAs out.  There should be a very complicated chromatin remodeling process involving histone deposition, histone modification changes and so on.  I think that the authors can think about taking these factors into account.

 

 
Posted by Anonymous reviewer on 06 Jun 2014 02:05:33 PM GMT