Dr. Sarkar Pradip

Dr. Sarkar Pradip

Professor

Basic Science, Parker University
2500 Walnut Hill Lane, Dallas, United States of America, 75229

plus Speciality

BIOCHEMISTRY

Biography:

Educational Backgropund: PhD in Biochemistry with specialization in thyroid hormone neuroendocrinology. Major research work is related to explore non-genomic action of thyroid hormones in adult mammalian central nervous system. Masters degree in Biochemistry with specialization in neurochemistry and biochemical pharmacology. Bachelors degree with Chemistry Honors. Research expertise in the area of thyroid neuroendocrinology, cancer biochemistry, basement membrane biology, neurochemistry. Mentored MS students. Received various national and international research grants. Published papers, attended conferecnes etc.

Academic positions:

Associate Professor in Biochemistry

Research interests:

Neuroendocrinology, nutrional biochemistry, neurochemistry.

Any other information:

Publications:
1. Sarkar PK, Ray AK (1992): A simple biochemical approach to differentiate synaptosomes and non-synaptic mitochondria from rat brain. Methods and Findings in Experimental and Clinical Pharmacology, 14(7): 493-497.
2. Sarkar PK, Ray AK (1993): Synaptosomal action of thyroid hormone: Changes in Na+-K+-ATPase activity in adult rat cerebral cortex. Hormone and Metabolic Research, 25: 1-3.
3. Sarkar PK, Ray AK (1994): Synaptosomal T3 content in cerebral cortex of adult rat in different thyroid states. Neuropsychopharmacology, 11: 151-155.
4. Sarkar PK, Ray AK (1998): Specific binding of triiodothyronine modulates Na+-K+-ATPase activity in adult rat cerebrocortical synaptosomes. Neuroreport, 9:1149-1152.
5. Chaudhuri A, Krishnan N (graduate student), Sarkar PK, Sinha AK, Sinha SS, Ray AK (1998): Octopamine titer in the circulating fluid of tropical tasar silkworm Antheria mylitta Drury (Lepidoptera: Saturniidae) and its response to injected estrogen during critical phase of diapause termination. Current Science, 74: 695-699.
6. Collorado P, Torre A, Kamphaus G, Maeshima Y, Hopfer H, Takahashi K, Volk R, Zamborsky ED, Herman S, Sarkar PK, Ericksen MB, Dhanabal M, Simons M, Post M, Kufe DW, Weichselbaum RR, Sukhatme VP, Kalluri R (2000): Anti-angiogenic cues from vascular basement membrane collagen. Cancer Research, 60(9): 2520-2526.
7. Sarkar PK and Ray AK (2001): Possible involvement of thyroid hormone in cholinergic neurotransmission in adult rat brain. Hormone and Metabolic Research 33: 270-275.
8. Chaudhuri A, Krishnan N (graduate student), Sarkar PK, Ray AK (2001): Octopamine regulated diapause termination and its response to exogenous L-DOPA during critical phase of pupal diapause in Tasar silkworm Antheraea mylitta Drury (Lepidoptera: Saturniidae). Entomon 26: 198-206.
9. Sarkar PK (2002): A quick assay for Na+-K+-ATPase specific activity. Zeitschrift fur Naturforschung, 57C (5/6): 562-564.
10. McDonald GA, Sarkar PK, Rennke H, Unemori E, Kalluri R, Sukhatme VP (2003): Relaxin increases ubiquitin dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo. American Journal of Physiology (Renal Physiol) 285: F59-F67.   
11. Sarkar PK, Ray AK (2003): Calcium mobilization within hypothyroid adult rat brain synaptosomes. Hormone and Metabolic Research 35 (9): 562-564.
12. Sarkar PK, Dey SS, Koley BN, Koley J, Ray AK (2004): Putative L-triiodothyronine receptors in the liver nuclei of mature tropical toad, Bufo melanostictus. Zeitschrift fur Naturforschung 59 C: 123-126.
13. Sarkar PK, Durga ND (graduate student), Morris JJ (graduate student), Martin JV (2006): In vitro thyroid hormone rapidly modulates protein phosphorylation in cerebrocortical synaptosomes from adult rat brain. Neuroscience 137 (1): 125-132.
14. Zeisberg M, Kramer K, Sindhi N, Sarkar PK, Upton M, Kalluri R (2006): De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane. Molecular and Cellular Biochemistry 283(1-2): 181-189.
15. Sarkar PK (2008): L-Triiodothyronine differentially and nongenomically regulates synaptosomal protein phosphorylation in adult rat brain cerebral cortex: role of calcium and calmodulin. Life Sciences 23: 82(17-18): 920-927.
16. Sarkar PK (2010): Subcellular levels of thyroid hormones in adult rat brain cerebral cortex. Thyroid Science 5 (4): CLS 1-4.   
17. Sarkar PK, Morris JJ (graduate student), Martin JV (2011): Calmodulin-dependent rapid nongenomic effect of L-triiodothyronine on synaptosomal protein phosphorylation in adult rat cerebral cortex. Indian Journal of Experimental Biology 49 (3): 169-176.

Invited Review:
18. Sarkar PK (2002): In quest of thyroid hormone function in mature mammalian brain. Indian Journal of Experimental Biology, 40: 865-873.

Ph. D. Thesis:
19. Sarkar, Pradip K. (1995): Thyroid hormone action in synaptosome of adult rat brain, Bose Institute, University of Calcutta, India.

Popular article:
20. De AK, Sarkar PK (1987): Heroin: Use and misuse. Science Reporter, November issue, p. 597-598.

Invited Book Chapter:
21. Ray AK, Sarkar PK (1997): The action of thyroid hormone in adult mammalian neuron: Synaptosome as a novel site.  In: Frontiers in Environmental and Metabolic Endocrinology, pp. 229-239. Ed. S. Maitra, University of Burdwan.
22. Sarkar PK (2012): “Quo Vadis?” Deciphering the code of nongenomic action of thyroid hormones in mature mammalian brain. In: "Thyroid Hormone", ISBN 980-953-307-179-9. Ed. N.K. Agarwal. Publisher: Intech, Croatia.  http://www.intechopen.com/articles/show/title/-quo-vadis-deciphering-the-code-of-nongenomic-action-of-thyroid-hormones-in-mature-mammalian-brain .

My Reviews of articles:  
23. Sarkar PK (2012): Verification of the relationship among the reproductive hormones and thyroid dysfunction in polycystic ovarian syndrome. [Review of the article 'Reproductive Hormone and Thyroid Hormone Profile in Polycystic Ovarian Syndrome ' by Malik I].WebmedCentral 3(6):WMCRW001894. http://www.webmedcentral.com/Article_Review_View/1894.
24. Sarkar PK (2012): Impact of induction of dietary stress by diabetes and starvation on adrenocortical anatomy and energy metabolism. [Review of the article ' Dietary Stress and Energy Metabolism: Evaluation of the Adrenal Cortex ' by Shotunde D].WebmedCentral 3(7):WMCRW002020. http://www.webmedcentral.com/Article_Review_View/2020.
25. Sarkar PK (2012): Awareness to improve educational aspects on prevalence of diabetes and its management: An assessment study of diabetes mellitus in India and Nepal. [Review of the article 'Assessment of Diabetes Mellitus in India and Nepal ' by Kalai R].WebmedCentral 3(7):WMCRW002021. http://www.webmedcentral.com/Article_Review_View/2021.

Books:
26. Sarkar, Pradip K. (2004): Facts of Life: A supplemental guide to accompany Human Biology. Pearson Custom Publishing, Boston, Massachusetts, USA. ISBN 0-536-80707-8.
27. Sarkar, Pradip K. (2006): Systems Physiology. Linus Publication, New York, USA. ISBN 1-93418804-2.

Manual:
28. Sarkar, Pradip K. (2007): A Laboratory Manual for Systems Physiology. New York Chiropractic College, Seneca Falls, New York.
29. Sarkar, Pradip K. (2008) – present): Biochemistry II Lecture Manual. Parker University, Dallas, Texas.
30. Sarkar, Pradip K. (2010 - present): Biochemistry II Work Book Manual. Parker University, Dallas, Texas.
31. Sarkar, Pradip K. (2010 – present): Biochemistry I Lecture Manual. Parker University, Dallas, USA.  
32. Sarkar, Pradip K. (2011 - present): Biochemistry I Work Book Manual. Parker University, Dallas, Texas.

Graduate Students’ Masters’ Thesis:  
33. Kadiri A (graduate student), Martin JV, Sarkar PK (2004): In search for specific ligand(s) that modulate nongenomic effect of thyroid hormone in adult rat brain: radioligand binding assay. Rutgers University, USA.
34. Morris JJ (graduate student), Martin JV, Sarkar PK (2005); In vitro actions of thyroid hormone on protein phosphorylation in a nucleus-free subcellular fraction from adult rat brain. Rutgers University, USA..
35. Biswas A (graduate student), Martin JV, Sarkar PK (2006): Effect of thyroid hormones on Na+-K+-ATPase specific activity of cerebrocortical synaptosomes from adult rat brain. Rutgers University, USA.

Papers under preparation:
1. Sarkar PK (2011-2012): Adrenergic-like effects of L-triiodothyronine in young adult rat brain.
2. Sarkar PK (2011-2012): Effect of L-triiodothyronine on adult rat brain synaptosomal Na+-K+-ATPase activity is inert to haloperidol, a dopamine receptor antagonist.
3. Ray AK, Brabant G, Hesch, Sarkar PK (2011-2012): Aminergic action of L-triiodothyronamine on release of prolactin and thyroid stimulating hormone from superfused rat pituitary in vitro.
4. Sarkar PK, Martin JV (2012): Regulation of 3H-muscimol binding at GABAA receptor by L-triiodothyronine and its analogs in adult rat brain membrane: a nongenomic action.
5. Sarkar PK, Martin JV (2012): Influence of chronic alcohol treatment on serum and synaptosomal levels of thyroid hormone.
6. Sarkar PK, Kalluri R (2012): Isolation and purification of collagen IV, laminin and perlecan from normal bovine liver: a comparison to corresponding proteins from mouse EHS tumor.  
7. Sarkar PK, Kalluri R (2012): Induction of early apoptosis in PC12 cells by NC1 fragment of collagen IV.
8. Sarkar PK, Ray PK (2012): Protein A alters nitrosomethylurea-induced changes in serum estrogen level and liver glutathione-S-transferase activity in young adult female rats.  

Conference Abstracts and Presentations:
1. Chandra M, Ray SK, Sarkar PK, Poddar MK (1988): Aldrin induced elevation of corticosterone level and cholinergic mechanism. 57thAnnual Meeting of Society of Biological Chemist (India), Abstract 255.
2. Sarkar PK, Ray AK (1990): An approach to identify thyroid hormone dependent processes in subcellular fraction of adult rat brain. Proceedings of 77th Session of Indian Science Congress, Section Physiology, Part 4, Abstract 11, pp. 139.
3. Sarkar PK, Ray AK (1990): Thyroid hormone involvement in synaptosomal function. 59th Annual Meeting of Society of Biological Chemists (India), Abstract END-2, pp. 63.
4. Sarkar PK, Ray AK (1991): Adrenergic effect of thyroid hormone (T3) on synaptosomal Na+-K+-ATPase activity in rat. 10th Annual Conference of Indian Council of Chemists, Section Biochemistry, Abstract BO-4, pp. 242.
5. Sarkar PK, Ray AK (1991): Thyroid hormone and membrane-related processes in synaptosomes. 60th Annual Meeting of Society of Biological Chemists (India), Section Endocrinology & Reproductive Biology, Abstract 147.
6. Sarkar PK, Ray AK (1992): Synaptosomal T3 concentration in altered thyroid states in rat. 61st Annual Meeting of Society of Biological Chemists (India), Section Endocrinology & Reproductive Biology, Abstract 174.
7. Sarkar PK, Ray AK (1992): Cholinergic neurotransmission and thyroid hormone in adult rat brain. Indian Journal of Physiology and Allied Science, 46(4) Supplement pp. 50.
8. Sarkar PK, Ray AK (1992): Synaptosomal ion transport as site of action of thyroid hormone in adult rat brain. Platinum Jubilee Symposium, Bose Institute, Calcutta, Abstract BE-10.
9. Sarkar PK, Ray AK (1994): Thyroid hormone action in mature synaptosomes may be involved with calcium signaling. Conference of Society of Biological Chemists (India), Calcutta, Abstract IC 5.
10. Sarkar PK, Ray AK (1994): Possible involvement of L-triiodothyronine in the membrane signal generation and transfer in mature mammalian neuron. International Conference on Neurobiology, Cochin, India, p.47.
11. Sarkar PK, Ray AK (1995): Critical alterations of the synaptosomal Na+-K+-ATPase and acetylcholinesterase activities in adult rat brain in relation to local T3 concentration at different thyroid states. XIII National Symposium on Reproductive Biology & Comparative Endocrinology, Abstract 60, pp. 71.
12. Sarkar PK, Ray AK, Murthy Ch. RK (1998): Nongenomic action of L-triiodothyronine (T3) in adult rat brain. XVI National Symposium on Reproductive Biology & Comparative Endocrinology, Trivandrum, India.
13. McDonald GA, Sarkar PK, Shurtleff B (graduate student), Rennke H, Unemori E, Kalluri R, Sukhatme VP (1999): Relaxin inhibits extracellular matrix deposition in an in vitro and in vivo model of renal fibrosis. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. 32nd Annual Meeting and Scientific Exposition of American Society of Nephrology, USA.
14.  McDonald GA, Sarkar PK, Shurtleff B (graduate student), Rennke H, Unemori E, Kalluri R, Sukhatme VP (2000): Relaxin increases ubiquitin dependent degradation of fibronectin. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA. 33rdAnnual Meeting and Scientific Exposition of American Society of Nephrology, Toronto, Canada.
15. Chaudhuri A, Krishnan N (graduate student), Sarkar PK, Ray AK (2000): Octopamine regulated diapause termination and its response to exogenous L-DOPA during critical phase of pupal diapause in Tasar silkworm Antheraea mylitta Drury (Lepidoptera: Saturniidae). Presented at Entomocongress 2000-Perspectives for the New Millennium (An International Meet), November 5-8,2000 at Techno perk, Trivandrum, India.
16. Sarkar PK, Cleveland TS (graduate student), Iyer S (graduate student), Martin JV (2001): Influence of chronic alcohol on serum and brain levels of thyroid hormone. Department of 16. Biology, Rutgers University, New Jersey. The Bulletin New Jersey Academy of Science, Section: Neurobiology, Volume 46 (1): 21, Kean University, New Jersey, USA.
17. Sarkar PK (2001): Thyroid hormone-neuron interaction: Some nongenomic phenomena in adult mammalian brain. Invited Lecture, August, Bose Institute, Calcutta, India.
18. Sarkar PK, Saidel W, Martin JV (2001): Regulation of 3H-muscimol binding by L-triiodothyronine in adult rat brain membranes: a non-genomic action. 31st Annual Meeting of Society for Neuroscience, California, USA.
19. Sarkar PK, Yuen J (undergraduate student), Mitchel CL (undergraduate student), Martin JV (2002): Alteration of 3H-muscimol binding at GABAA receptor by L-triiodothyronine and its analogs in adult rat brain membranes. Department of Biology, Rutgers University, New Jersey. The Bulletin New Jersey Academy of Science, Section: Neurobiology, Volume 47(1): 16, Kean University, New Jersey, USA.
20. Sarkar PK, Martin JV (2003): Effects of L-triiodothyronine on phosphorylation of tyrosyl residues in a cell-free preparation. The Bulletin New Jersey Academy of Science, Section: Neurobiology. 99.
21. Sarkar PK, Durga ND (graduate student), Martin JV (2003): In vitro actions of thyroid hormone on protein phosphorylation in a nucleus-free subcellular fraction from adult rat brain. 33rd Annual Meeting of Society for Neuroscience. November 8-12, New Orleans, USA.
22. Yuen J (undergraduate student), Sarkar PK (2004): L-Triiodothyronine-induced inhibition of synaptosomal Na+-K+-ATPase activity in mature rat brain cerebral cortex might involve G-protein signaling. Rutgers Undergraduate Research Fellows Program Poster Presentation, April 28, Rutgers University, New Brunswick, New Jersey, USA.
23. Sarkar PK, Morris JJ (graduate student), Martin JV (2004): In vitro actions of thyroid hormone on tyrosine-directed phosphorylation of proteins in a nucleus-free subcellular fraction from adult rat brain. 34th Annual Meeting of Society for Neuroscience. October 23-27, San Diego, California, USA.
24. Biswas A (graduate student), Martin JV, Sarkar PK (2005): Effect of thyroid hormones on Na+-K+ ATPase specific activity in synaptosomes from adult rat brain. University of Medicine & Dentistry New Jersey Graduate Research Annual Poster Presentation. October 13th, 2005. New Jersey, USA.
25. Sarkar PK (2006): Thyroid hormones non-genomically regulate protein phosphorylation in mature rat brain. 9th Annual New York Chiropractic College Research Symposium, January 24 & 26, 2006. Seneca Falls, New York.
26. Lavalliere K (Doctor of Chiropractic student), Sarkar PK (2006): Nongenomic Actions of Thyroid Hormones on Synaptosomal Na+-K+-ATPase in Adult Rat Brain. 9th Annual New York Chiropractic College Research Symposium, January 24 & 26, 2006. Seneca Falls, New York.
27. Biswas A (graduate student), Martin JV, Sarkar PK (2006): Modulation of the specific activity of Na+-K+ ATPase in synaptosomes from adult rat brain by thyroid hormone metabolites. 10th Annual Research Day, University of Medicine & Dentistry New Jersey Graduate Research Annual Poster Presentation, March 16, 2006. New Jersey, USA.
28. Biswas A (graduate student), Martin JV, Sarkar PK (2006): Inhibition of the specific activity of Na+-K+ ATPase by thyroid hormone analogues and adrenergic drugs in synaptosomes from adult rat brain.  51st Annual Meeting of New Jersey Academy of Science April 8, 2006, New Jersey Institute of Technology, Newark, New Jersey.
29. Sarkar PK (2006): L-Triiodothyronine differentially regulates synaptosomal protein phosphorylation in adult rat brain, in vitro: role of calcium and calmodulin. 36th Annual Meeting of Society for Neuroscience. October 14-18, Atlanta, Georgia, USA.
30. Sarkar PK (2007): L-Triiodothyronine induces protein phosphorylation nongenomically in young adult rat cerebrocortical synaptosomes: role of calcium. 10th Annual New York Chiropractic College Research Symposium, January 23 & 27, 2006. Seneca Falls, New York.
31.  Thomas K (Doctor of Chiropractic student), Sarkar PK (2007): Search for second messenger-mediated regulation of thyroid hormone-induced synaptosomal protein phosphorylation in adult rat brain. 10th Annual New York Chiropractic College Research Symposium, January 23 & 27, 2006. Seneca Falls, New York.
32. Sarkar PK (2007): L-Triiodothyronine nongenomically regulates protein kinase A and Ca2+/calmodulin-dependent protein kinase II-mediated protein phosphorylation in mature rat brain, in vitro. 37th Annual Meeting of Society for Neuroscience. November 3-7, San Diego, California, USA.
33. Sarkar PK (2008): Thyroid hormone modulates protein phosphorylation through calcium-dependent kinase pathways in adult rat brain cerebral cortex. 11th Annual New York Chiropractic College Research Symposium, January 29 & 31. Seneca Falls, New York.
34. Sarkar, PK (2008): a2-Adrenergic receptor activation by clonidine exerts independent action on L-triiodothyronine-synaptosomal membrane receptor interaction and phosphorylation of a 53 kD synaptosomal protein in adult rat brain cerebral cortex. . 38th Annual Meeting of Society for Neuroscience. November 3-7, Maryland, Washington DC, USA.
35. Odhwani, A and Sarkar PK (2010): Effect of spinal manipulation and immune system: a literature review. Submitted to Association of Chiropractic Colleges Educational Conference and Research Agenda Conference (ACC-RAC) 2011.
36. Sarkar, PK (2011): Nongenomic actions of L-triiodothyronine modulate calcium and calmodulin-dependent protein phosphorylation in mature rat cerebrocortical synaptosomes. Guest Speaker in International Forum of Neuroscience Conference to be held in Nanjing, China, July 8-10, 2011.

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