Dr. Mishra Paras Kumar

Dr. Mishra Paras Kumar

Assistant Professor

Physiology & Biophysics, University of Louisville
Louisville, Kentucky, United States of America, 40202

plus Speciality

PHYSIOLOGY

Biography:

Dr. Mishra obtained his M.S. and Ph.D. from Banaras Hindu University, a very reputed university in India. He started his career in physiology in the year 2008, when he joined department of Physiology & biophyscis, University of Louisville, KY, USA. He has been promoted to Assistant Professor in the year 2010. His major interest areas are microRNomics of heart failure, stem cell therapy, mechanisms of heart failure in diabetes, contribution of extracellular matrix and matrix metalloproteinases in pathological cardiac remodeling. His reseach work has been recognized with several interpartionla awards and invited talk. He is actively engaged in scientific community as Reviewer of American Heart Association grants, Editor of Book, Member of Editorial board of internationally reputed peer reviewed Journals, Managing Editor of “Journal of diabetes and metabolism”, Expert Judge, committee member, reviewer of journals and so on. Currently, he is funded with American heart association grant and is mentoring a Research Associate and three M.S. students.

Academic positions:

Assistant Professor.

Research interests:

Heart failure, diabetes, miRNA, stem cell, exercise.

Any other information:

PEER REVIEWED PUBLICATIONS
Research Articles:
1. Chavali. V, Tyagi SC, Mishra PK*. MicroRNA-133a regulates DNA methylation in diabetic cardiomyocytes. Biochem Biophys Res Commun. Online ahead of print. http://dx.doi.org/10.1016/j.bbrc.2012.07.105. * Corresponding author.
2. Mishra PK, Chavali. V, Metreveli N, Tyagi SC. Ablation of MMP9 induces survival and differentiation of cardiac stem cell into cardiomyocytes in the diabetic heart; a role of extracellular matrix. Can. J. Physiol. Pharmacol. 90: 353-360. 2012. * Corresponding author.
3. Sen U, Sathnur PB, Kundu S, Givvimani S, Coley D, Mishra PK, Qipshidze N, Tyagi N, Metreveli N, Tyagi SC. Increased endogenous H2S generation by CBS, CSE and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia. Am J Physiol Cell Physiol. 2012 Epub ahead of print. PMID: 22517358.
4. Qipshidze N, Metreveli N, Mishra PK, Lominadze D, Tyagi SC. Hydrogen sulfide mitigates cardiac remodeling during myocardial infarction via improvement of angiogenesis. Int. J. Biol. Sci. 8(4):430-41. 2012. PMID: 22419888.
5. *Mishra PK, Awe O, Metreveli N, Qipshidze N, Joshua IG, Tyagi SC. Exercise mitigates the homocysteine - beta2-adrenergic receptor interactions to ameliorate contractile dysfunction in diabetes. Int. J. Phys. Pathophy. Phar. 3(2):97-106. 2011. PMID: 21760968
* Corresponding author.
6. Basu P, Qipshidze N, Sen U, Givvimani S, Munjal C, Mishra PK, Tyagi SC. Chronic hyperhomocysteinemia causes vascular remodeling by instigating vein phenotype in artery. Arch. Physiol. Biochem. 117(5):270-82. 2011. PMID: 21838575.
7. Givvimani S, Qipshidze N, Tyagi N, Mishra PK, Sen U, Tyagi SC. Synergism between arrhythmia and hyperhomocysteinemia in structural heart disease Int. J. Phys. Pathophy. Phar. 3(2):107-19. 2011. PMID: 21760969.
8. *Mishra PK, Givvimani S, Metreveli N, Tyagi SC. Attenuation of beta2-adrenergic receptors and homocysteine metabolic enzymes cause diabetic cardiomyopathy. Biochem Biophys Res Commun. 15; 401(2):175-81. 2010. PMID: 20836991.
* Corresponding author.
9. Mishra PK, Tyagi N, Sen U, Joshua IG. Tyagi SC. Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempol. Cardio. Diabetol. 9:49. 2010. PMID: 20828387
10.Mishra PK, Metreveli N, Tyagi SC. MMP-9 gene ablation and TIMP-4 mitigate PAR-1 mediated cardiomyocyte dysfunction: A plausible role of dicer and miRNA. Cell Biochem. Biophys. 57(2-3):67-76. 2010. PMID: 20422465.
11.Mishra PK, Tyagi N, Sen U, Givvimani S, Tyagi SC. H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure. Am J Physiol Heart Circ Physiol. 298 (2): H451-6. 2010. PMID: 19933416.
12.Givvimani S, Tyagi N, Sen U, Mishra PK, Qipshidze N, Munjal C, Vacek JC, Abe OA, Tyagi SC. MMP-2/TIMP-2/TIMP-4 versus MMP-9/TIMP-3 in transition from compensatory hypertrophy and angiogenesis to decompensatory heart failure. Arch Physiol Biochem. 116 (2): 63- 72: 2010. PMID: 20230216.
13.Mishra PK, Tyagi N, Kundu S, Tyagi SC. MicroRNAs are involved in homocysteine induced cardiac remodeling. Cell Biochem. Biophys. 55(3):153-62.2009. PMID: 19669742.
14.Kundu S, Kumar M, Sen U, Mishra PK, Tyagi N, Metreveli N, Lominadze D, Rodriguez W, Tyagi SC. Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts and iNOS/CBS double knockout mice. J Cell Biochem. 106:119-26; 2009. PMID: 19021146
15.Moshal KS, Kumar M, Tyagi N, Mishra PK, Metreveli N, Rodriguez WE, Tyagi S C. Restoration of contractility in hyperhomocysteinemia by cardiac-specific deletion of NMDA-R1. Am J Physiol Heart Circ Physiol. 296(3):H887-92. 2009. PMID: 19181966.
16.Kumar M, Tyagi N, Moshal KS, Sen U, Kundu S, Mishra PK, Givvimani S, Tyagi S C. Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery. Neurochem Int. 53:214-9; 2008. PMID: 18725259.

Review Articles:

17.Tyagi AC, Sen U, Mishra PK*. Synergism of miRNA and stem cell: A novel therapeutic approach for diabetes mellitus and cardiovascular diseases. Curr. Diabetes. Rev. 7: 367-376; 2011. PMID: 21864292. * Corresponding author.
18.Mishra PK, Singh SR, Joshua IG, Tyagi SC. Stem cells as a therapeutic target for diabetes. Front. Biosci. 15:461-477; 2010. PMID: 20036830.
19.Sen U, Mishra PK, Tyagi N, Tyagi SC. Homocysteine to hydrogen sulfide or hypertension. Cell Biochem Biophys. 57: 49-58; 2010. PMID: 20387006.
20.Tyagi N, Mishra PK, Tyagi SC. Homocysteine, hydrogen sulfide (H2S) and NMDA - receptor in heart failure. Ind. J. Biochem Biophys. 46: 441-446; 2009. PMID: 20361707.
21.Mishra PK, Tyagi N, Kumar M, Tyagi SC. MicroRNAs as a therapeutic target for cardiovascular disease. J Cell. Mol. Med. 13:778-89; 2009. PMID: 19320780.

Chapter in Books:

22.*Mishra PK, Singh SR, Sharma R, Tyagi SC. Stem cell for myocardial regeneration. In Shree Ram Singh, Paras K. Mishra and Stevan X. Hou (Eds.); Stem cells: organogenesis and cancer. Transworld Research Network, India, 2010, pp. 119-126. *Corresponding author.
23.Moshal K, Kumar M, Tyagi N, Mishra PK, Kundu S, Tyagi SC. Oxidative and proteolytic stress in homocysteine associated cardiovascular diseases. In H. Sauer et al. (Eds.); Studies on cardiovascular disorders. Springer science + Business Media, LLC., 2010, pp 139-148. DOI: 10.1007/978-1-60761-600-9_7.

Publications from Conferences:

24.Chavali V, Tyagi N, Tyagi SC, Mishra PK. MiR-133 as an epigenetic regulator of diabetic heart failure. FASEB J, 26: 1057.22, 2012.
25.Mishra PK, Joshua IG, Tyagi SC. Exercise mitigates beta-2 adrenergic receptor dysfunction by decreasing homocysteine in diabetes. FASEB J, 26: 1076.2, 2012.
26.Tyagi N, Narayanan N, Mishra PK, Qipshidze N, Givvimani S, Tyagi SC, Epigenetic reprogramming of mitochondrial dysfunction in hyperhomocysteinemia. FASEB J, 26: 701.17, 2012.
27.Tyagi N, Qipshidze N, Givvimani S, Mishra PK, Lominadze D, Tyagi SC. Homocysteine induces alteration of tight junction proteins in brain endothelial cells. Stroke, 43: A3754, 2012.
28.Mishra PK, Metreveli N, Chavali V, Tyagi N, Qipshidze N, Sen U, Joshua I G, Tyagi SC. Role of MMP9 in cardiac stem cell differentiation and autophagy. FASEB J, 26: 1060.10, 2012.
29.Qipsidze N, Munjal C, Tyagi N, Mishra PK, Sen U, Givvimani S, Metreveli N, Lominadze D, Tygai SC, Mechanism of right ventricular remodeling in mouse model of pulmonary hypertension. Hypertension, 58:e33-e83; 2011.
30.Tyagi N, Qipshidze N, Munjal C, Metreveli N, Mishra PK, Sen U, Givvimani S, Lominadze D, Tyagi SC. H2S ameliorates oxidative stress and protects the brain against cerebro-vascular remodeling in ischemia/reperfusion injury. Hypertension, 58:e33-e83; 2011.
31.Mishra PK, Metreveli N, Tian Q, Qipshidze N, Tyagi N, Sen U, Givvimani S, Joshua I G, Liu C, Tyagi SC. MiR-133 ameliorates MMP9 induced diabetic cardiomyopathy. Hypertension, 58:e33-e83; 2011.
32.Sen U, Givvimani S, Qipshidze N, Mishra PK, Metreveli N, Tyagi SC. Increased endogenous H2S generation by gene therapy improves renovascular function in CBS+/- mice. Hypertension, 58:e33-e83; 2011.
33.Givvimani S, Sen U, Tyagi N, Mishra PK, Munjal C, Qipshidze N, Metreveli N, Tyagi SC.TIMP-2 mutant decreases MMP-2 activity and auguments pressure overload induced left ventricular dysfunction and heart failure. Hypertension, 58:e33-e83; 2011.
34.Tyagi N, Qipshidze N, Givvimani S, Mishra PK, Lominadze D, Tyagi SC. Homocysteine induces alterations of tight junction proteins in brain endothelial cells. Stroke, 43: A3754; 2012.
35.Mishra PK, Awe O, Metreveli N, Qipshidze N, Munjal C, Tyagi N, Tyagi SC. Exercise ameliorates diabetic cardiomyopathy by inducing beta2-adrenergic receptors and miR-133a, and attenuating MMP-9. FASEB J, 25: 1032.4; 2011.
36.Tyagi N, Qipshidze N, Munjal C, Metreveli N. Dankowski A, Mishra PK, Sen U, Lominadze D, Givvimani S, Tyagi SC. Hydrogen Sulfide ameliorates mitochondrial MMP-9 mediated mitochondria remodeling in cerebral ischemia. FASEB J, 25: 650.7; 2011.
37. Sen U, Qipshidze N, Givvimani S, Mishra PK,Munjal C, Tyagi N, Tyagi SC. Hydrogen sulfide mitigates homocysteine-mediated mitophagy. FASEB J, 25: 643.25; 2011.
38.Munjal C, Tyagi N, Qipshidze N, Mishra PK, Givvimani S, Sen U, Lominadze D, Tyagi SC. The siRNA targeting MMP-9 mitigates Homocysteine induced dysruption of barrier integrity in Human intestinal microvascular cells. FASEB J, 25: 1066.7; 2011.
39.Qipshidze N, Mishra PK, Metreveli N, Lominadze D, Tyagi SC. Hydrogen sulfide improves angiogenesis and regulates cardiac function and structure during myocardial infarction in mice. FASEB J, 25: 1092.10; 2011.
40.Mishra PK, Givvimani S, Sen U, Abe OA, Tyagi N, Basu P, Munjal C, Tyagi SC. Role of dicer in diabetic cardiomyopathy through dysregulation of MMP-9 and TIMP-4. FASEB J, 24: 978.19; 2010.
41.Kandel M, Tyagi N, Qisphidze N, Munjal C, Basu P, Givvimani S, Abe O, Mishra PK, Sen U, Tyagi SC. Folic acid mitigated homocysteine-mediated decrease in bone blood flow and bone remodeling. FASEB J, 24: 630.7; 2010.
42. Givvimani S, Jala R, Mishra PK, Sen U, Tyagi N, Qipshidze N, Munjal C, Tyagi SC. Functional heterogeneity in vascular remodeling (MMP-9-/- and PAR-1-/+) in hyperhomocysteinemic (CBS-/+) and diabetic (Akita, Ins2-/+) mice. FASEB J, 24: 599.6; 2010.
43.Mishra PK, Metreveli N, Givvimani S, Panguluri SK, Sen U, Tyagi N, Basu P, Munjal C, Joshua IG, Tyagi SC. Ablation of MMP-9 ameliorates miR-1 and -133 mediated cardiac dysfunction in insulin2 mutant diabetic mice. Hypertension, 56: e50 - e166; 2010.
44.Tyagi N, Qipshidze N, Givvimani S, Kandel M, Mishra PK, Sen U, Johar A, Tyagi SC. Tetrahydrocurcumin ameliorates mtMMP-9 mediated mitophagy and mitochondria remodeling in Stroke. FASEB J, 24: 604.4; 2010.
45.Basu P, Qipshidze N, Sen U, Mishra PK, Tyagi S. Blood flow regulates vasculature by maintaining elastin /collagen and MMP/ TIMP ratio. FASEB J, 24: 790.3; 2010.
46.Munjal C, Falcon JF, Qipshidze N, Mishra PK, Tyagi SC. DDAH-2 & eNOS in Mesenteric Vascular Remodeling : Role of Fenugreek. FASEB J, 24: 774.7; 2010.
47.Mishra PK, Tyagi N, Kumar M, Kumar M, Kundu S, Givvimani S, Sen U, Tyagi SC. Role of microRNAs in homocysteine-induced oxidative stress. FASEB J, 23: 1038.9; 2009.
48.Kumar M, Givvimani S, Puspkumar SB, Mishra PK, Kundu S, Rodriguez-Alvarez WE, Tyagi N, Sen U, Tyagi SC. Cerebroprotective role of tetrahydro curcumin in hyperhomocysteinemic ischemic mine by regulating NF-kB. FASEB J, 23: 614.7; 2009.
49.Tyagi N, Givvimani S, Kumar M, Kundu S, Gillespie W M, Mishra PK, Sathnur P, Lominadze D, Sen U, Tyagi SC. Activation of GABA- receptor Protects Mitochondria and Reduces Cerebral ischemia. FASEB J, 23: 614.8; 2009.
50.Mishra PK, Metreveli N, Givvimani S, Kundu S, Tyagi N, Qipshdze N, Sen U, Basu P, Abe OA, Gillespie WM, Munjal C, Vacek J, Tyagi SC. Down regulation of dicer involved in MMP-9 mediated cardiomyocytes dysfunction. Hypertension, 54: e26 - e127; 2009.

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