Dr. Potempa Lawrence

Dr. Potempa Lawrence

Professor

College of Pharmacy, Roosevelt University
1400 N Roosevelt Blvd, Schaumburg, United States of America, 60173

plus Speciality

IMMUNOLOGY

Biography:

PhD Biochemistry - Northwestern University Feinberg College of Medicine, Chicago, IL Postdoctoral Fellow - Microbiology/Immunology - Rush Medical University, Chicago, IL Assistant Professor and Assistant Scientist - Rush Presbyterian St Luke's Medical Center and University, Chicago, IL Vice President R&D/Chief Science Officer, Immtech Pharmaceuticals, Inc, Vernon Hills, IL Founder, Vice President R&D/Chief Science Officer, Next Era Therapeutics, Inc, Vernon Hills, IL Founder, President/Chief Science Officer, Acphazin, Inc, Deerfield, IL Founding Faculty, Asso Professor of Biochemistry and Immunology, College of Pharmacy, Roosevelt University, Schaumburg, IL

Academic positions:

Founding Faculty, Asso Professor of Biochemistry and Immunology, College of Pharmacy, Roosevelt University, Schaumburg, IL

Research interests:

My laboratory’s research interests are in innate immunity and inflammation. Specifically, we are evaluating structure/function relationships of C-reactive protein as a biological response modifier. We have uncovered a mechanism whereby the widely studied serum-soluble pentameric CRP disc (pCRP) dissociates and undergoes an irreversible conformational rearrangement into a potent pro-inflammatory molecule termed modified, monomeric CRP (mCRP). mCRP can regulate complement activation and lipoprotein metabolism. Furthermore, when mCRP gets reduced, it becomes a potent activator of cellular responses by interacting with lipid rafts motifs and triggering intracellular signaling pathways that promote an aggressive inflammatory response. Our laboratory is investigating the how CRP isoforms can be used and pharmacologically controlled for therapeutic benefit.

Any other information:

Consultant - ImmvaRx Inc - Cancer Vaccine Company Consultant - Angiogen, Inc - Antiangiogenesis Company

What I think of the idea behind WebmedCentral and WebmedCentral plus:

In development - have an open mind right now