Dr. Kaufman Randal

Dr. Kaufman Randal


Degenerative Disease Research at Sanford Burnham Medical Research Medical Institute
Greater San Diego Area , United States of America

plus Speciality



Kaufman pioneered the development of recombinant protein therapeutics, significantly clotting factors that revolutionized hemophilia therapy. He elucidated the critical roles of cellular machinery for protein folding, processing and trafficking that contributed significantly to the discovery of a novel signaling pathway, the unfolded protein response, and its importance in human disease.

Academic positions:

Experience 1. 2011 – Present (1 year): Director, Degenerative Disease Research; Sanford-Burnham Medical Research Institute 2. 1994 – Present: Professor; University of Michigan 3. 1994 – 2011: Investigator; Howard Hughes Medical Institute 4. 1983 – 1994: Director; Genetics Institute 5. 1974 – 1979: graduate student; Stanford University

Research interests:

Aging, Stem Cell Research, Molecular Biology, Neuroscience

Any other information:

Publications 1. Thioredoxin-Interacting Protein Mediates ER Stress-Induced ? Cell Death through Initiation of the Inflammasome. 2. The impact of the unfolded protein response on human disease. 3. Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction. 4. Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity. 5. RNA surveillance is required for endoplasmic reticulum homeostasis. 6. PKR in DSS-induced colitis: A matter of genetic background and maternal microflora? 7. Endoplasmic reticulum stress and type 2 diabetes. 8. PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. 9. Integrated stress response modulates cellular redox state via induction of cystathionine ?-lyase: cross-talk between integrated stress response and thiol metabolism. 10. A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation. 11. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. 12. Beta-cell failure, stress, and type 2 diabetes. 13. Bioengineering of coagulation factor VIII for efficient expression through elimination of a dispensable disulfide loop. 14. Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. 15. ER stress and its functional link to mitochondria: role in cell survival and death. 16. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of ?1-antitrypsin. 17. Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. 18. Eukaryotic initiation factor 2alpha phosphorylation is required for B-cell maturation and function in mice. 19. iRhoms: ERADicating the messenger in growth control signaling. 20. The unfolded protein response transducer IRE1? prevents ER stress-induced hepatic steatosis.

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