Prof. Barreto George

Prof. Barreto George

Professor of Neurosciences

Department of Biochemistry. Pontificia Universidad Javeriana
Cra 7 40-62, Bogota, Colombia

plus Speciality

NEUROSCIENCES

Biography:

2002 B.Sc. (Physical Therapy) Tiradentes University Project: Diabetic Neuropathy: Medical concerns in a Physiotherapeutic approach. 2003 Specialization (Respiratory Physical Therapy) Castelo Branco University Project: Physiotherapeutic techniques applied to Obstructive Pulmonary Diseases. 2005 M.Sc. (Health Sciences – Biochemistry) Federal University Rio Grande do Norte, Brazil Project: Study of the effects of benzene and toluene on isolated rat brain and liver mitochondria. 2009 Ph.D. (Biological Sciences – Neurosciences) Universidad Complutense Madrid, Spain Project: Regulation of reactive glia by androgens and estrogens after brain injury in rats. 2011 Postdoctoral Research Fellow – Neurosciences. Department of Anesthesia. Stanford University School of Medicine (2009-2011), USA. Mentors: Rona G. Giffard (rona.giffard@stanford.edu) and Carla J. Shatz (cshatz@stanford.edu).

Academic positions:

1- Professor. Department of Nutrition and Biochemistry. Pontificia Universidad Javeriana. March 2011- present 2- Member of the Graduate Committee program. Faculty of Sciences 3- Research Group “Cellular and Molecular Therapy” 4- Coordinator, Biochemistry Emphasis. 5- Theme Editor (Biochemistry and Neurosciences) – Universitas Scientiarum 6- Member of Committee. Institute for Aging Studies – Faculty of Medicine.

Research interests:

For decades, astrocytes have been considered to be non-excitable support cells that are relatively resistant to brain injury. This view has changed radically during the past twenty years. Multiple essential functions are performed by astrocytes in normal brain.Astrocytes are dynamically involved in synaptic transmission, metabolic and ionic homeostasis, and inflammatory maintenance of the blood-brain barrier. Advances in our understanding of astrocytes include new observations about their structure, organization, and function. Astrocytes play an active and important role in the pathophysiology of brain damage. Brain injury impairs mitochondrial function and this is accompanied by increased oxidative stress, leading to prominent astrogliosis, which involves changes in gene expression and morphology, and therefore glial scar formation. Recent works have demonstrated a protective role of reactive astrocytes after brain injury. Nevertheless, others have pointed to an inhibitory role of astrocytes in axonal regeneration after injury. Reactive astrogliosis is a complex phenomenon that includes a mixture of positive and negative responses for neuronal survival and regeneration. Reactive astroglia maintains the integrity of the blood-brain barrier and the survival of the perilesional tissue, but may prevent axonal and damaged tissue regeneration. Neuroprotective strategies aiming at reducing gliosis and enhance brain plasticity are of potential interest for translational neuroscience research in brain injuries. In this context, neurosteroids and mesenchymal stem cells have shown to be promising strategies to protect brain against injury, as their effects may rely on reducing gliosis, brain inflammation and potentially modulating recovery from brain injury by engaging mechanisms of neural plasticity. Our group is interested on how potential theurapeutical strategies may control astrogliosis and therefore improve neuronal survival, focusing particularly on the two-sided role of reactive astrocytes, which is an experimental paradigm helpful in discriminating destructive from protective mechanisms after brain injury.

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