Dr. Lobie Peter

Dr. Lobie Peter

Professor

Senior Principal Investigator Cancer Science Institute of Singapore
Cootamundra, New South Wales, Austria

plus Speciality

CANCER

Biography:

Peter Lobie obtained a B.Med.Sci. (Distinction) and MBBS (Medicine First Class Honours) in 1992 from the University of Queensland in Australia. He was awarded the highest accolade from the University in the form of a University Medal. His postdoctoral work was undertaken at the Karolinska Institute in Sweden where he also obtained a PhD. He has consecutively held faculty positions in Singapore and New Zealand. He was also New Zealand’s first chair of Breast Cancer funded by the Breast Cancer Research Trust. He is now is Professor and Senior Principal Investigator at the newly formed Cancer Science Institute of Singapore. Peter Lobie is author of over 120 publications and is an international authority on molecular mechanisms of hormone action. Recent emphasis in his laboratory has focused on the capacity of hormones or secreted proteins to initiate or progress cancer and thereby evaluation of individual molecules for their potential therapeutic application. This latest focus has produced intellectual property of potential enormous utility and value. One of the cancer programmes has been licensed in 2008 to an international partner for clinical development. He is the recipient of multiple local and international awards and has been appointed a Fellow (Academician) of the Royal Society of New Zealand. Prof. Lobie is the inventor on 11 patent families and has been associated heavily with industry during his time in Sweden (Pharmacia), has consulted for Pfizer Inc. and Metabolic Inc. and in New Zealand served as a senior consultant to Neuren Pharmaceuticals as head of their cancer research programme. He is the founding scientist of Perseis Therapeutics Ltd and Saratan Therapeutics Ltd, two new entities focused on development of therapeutics to novel cancer target molecules. He is also a founding shareholder in Wuhan Long Ke Ltd. He was an editorial board member of Endocrinology among a number of other international journals and served on the Annual Meeting Steering Committee of The Endocrine Society (USA). He has served as a reviewer for more than 40 academic journals and more than 15 local and international granting agencies.

Academic positions:

Education

Primary Education:

1. 1972-1974: St. Joseph's Convent, Tenterfield, New South Wales, Australia.
2. 1975-1979: St. Joseph's Convent, Biloela, Queensland, Australia.

Secondary Education:

1. 1980: Biloela State High School, Biloela, Queensland, Australia.
2. 1981-1984: St. Brendan's College, Yeppoon, Queensland, Australia.

Tertiary Education :

1. The University of Queensland, Australia 1985-1992.
2. 1985: Science 1
3. 1986-1988: Medicine I-III
4. 1989-1990: Bachelor of Medical Science with Distinction
5. 1990-1992: Medicine IV-VI
6. 1992: Bachelor of Medicine and Bachelor of Surgery with First Class Honours
7. 1994: Doctor of Philosophy (Doctor i Medicinsk Vetenskap) (Molecular Endocrinology), Karolinska Institute, Department of Medical Nutrition, Stockholm, Sweden.

University Academic Prizes

1. Department of Anatomy Vacation Scholarship 1987/88
2. The Herbert John Wilkinson Memorial Prize in Anatomy 1988
3. Department of Physiology and Pharmacology Vacation Scholarship 1988/89
4. The William Nanthaniel Robertson Scholarship 1989
5. The Douglas H.K. Lee Family Scholarship 1989
6. The John Weinholt Memorial Scholarship in Anatomy and Physiology 1989
7. The Sullivan and Niccolaides Medical Science Prize 1989
8. The National Health and Medical Research Council Medical Undergraduate
     Scholarship 1989
9. The University Medal for Outstanding Scholarship 1992

Research interests:

Cancer, Pharmacology

Any other information:

Publications

1. Walker DG, Breipohl W, Simon-Taha A, Lincoln D, Lobie PE, Garcia-Aragon J (1990) Cell-dynamics and maturation within the olfactory epithelium proper of the mouse- a morphometric analysis. Chem. Senses 15: 741-753
2. Lobie, P.E., Breipohl, W.,Waters, M.J. (1990) Growth hormone receptor expression in the rat gastrointestinal tract. Endocrinology 126: 299-306
3. Lobie, P.E., Breipohl, W., Garcia-Aragon, J., Waters, M.J. (1990) Cellular localization of the growth hormone receptor/ binding protein in the male and female reproductive systems. Endocrinology 126: 2214-2221
4. Waters, M.J., Barnard, R., Lobie, P.E., Lim, L., Hamlin, G., Spencer, S.A., Hammonds, R.G., Leung, D.W., Wood, W.I. (1990) Growth hormone receptors: their structure, location and role. Acta. Paed. Scand. 366: 60-72
5. Lobie, P.E., Breipohl, W., Lincoln, D.T., Garcia-Aragon, J., Waters, M.J. (1990) Localization of the growth hormone receptor/binding protein in skin. J. Endocrinol. 126: 467-472
6. Lincoln, D.T., Waters, M.J., Breipohl, W., Sinowatz, F., Lobie, P.E. (1990) Growth hormone receptor expression in the proliferating rat mammary gland. Acta Histochem. 40 : 47-49
7. Breipohl, W., Lincoln, D.T., Hughes, L., Taha, A., Lobie, P.E., Amselgruber, W., Sinowatz, F., Gabius, H.J. (1990) Carbohydrate binding proteins in the proliferating and lactating mammary gland. Acta Histochem. 40: 43-47
8. Lobie, P.E., Barnard, R., Waters, M.J. (1991) The nuclear growth hormone receptor/binding protein: Antigenic and physicochemical characterization. J. Biol. Chem. 266: 22645-22652
9. Waters, M.J., Lobie, P.E., Gobius, K.S., Rowlinson, S.W., Garcia-Aragon, J., Zhang, C., Young, W.G., Bastiras, S., Robbins, A., Wells, J.R., Barnard, R. (1991) Growth hormone receptors- recent developments. Proc. Endo. Soc. Aust. 34: 145-150
10. Sinowatz, F., Breipohl, W., Waters, M.J., Lincoln, D., Lobie, P.E., Amselgruber, W. (1991) Growth hormone receptor expression in the Dunning R 3327 prostatic carcinoma of the rat. Prostate 19: 273-278
11. Garcia-Aragon, J., Lobie, P.E., Muscat, G.E.O., Gobius, K.S., Norstedt, G., Waters, M.J. (1992) Prenatal expression of the growth hormone receptor/binding protein in the rat: a role for growth hormone in embryonic and fetal development? Development 114: 869-876
12. Lobie, P.E., Garcia-Aragon, J., Waters, M.J. (1992) Growth hormone regulation of gastric structure and function in the GH deficient rat: upregulation of intrinsic factor. Endocrinology 130: 3015-3024
13. Lobie, P.E., Garcia-Aragon, J., Wang, B.S., Baumbach, W.R., Waters, M.J. (1992) Cellular localization of the growth hormone binding protein in the rat. Endocrinology 130: 3057-3065
14. Möller, C., Hansson, A., Enberg, B., Lobie, P.E., Norstedt, G. (1992) Growth hormone induction of tyrosine phosphorylation and activation of mitogen activated protein kinases in cells transfected with rat GH receptor cDNA. J. Biol. Chem. 267: 23403-23409
15. Waters, M.J., Rowlinson, S.W., Gobius, K.S., Lobie, P.E., Garcia-Aragon, J., Muscat, G.E.., Bastiras, S., Robbins, A., Zhang , C., Young, W.G., Barnard, R (1993) Biochemistry and cellular
distribution of the growth hormone receptor., In E.E. Muller (Ed.) Growth hormones and somatomedins during life span. Springer Verlag, Heidelberg. pp 26-43.
16. Young, W.G., Zhang, C.Z., Li, H., Lobie, P.E., Waters, M.J. (1993) Cell proliferation in odontogenic mesenchyme is influenced by growth hormone: a bromodeoxyuridine immunocytochemistry and morphometric study in the Lewis dwarf rat. Arch. Oral. Biol.  38: 207-214
17. Waters, M.J., Lobie, P.E., Garcia-Aragon, J., Rowlinson, S.W., Gobius, K.S., Bastiras, S., Robbins, A., Zhang, C., Young, W.G., Muscat, G.E., Barnard, R. (1993) Structure, localization and role of the growth hormone receptor., In Growth and sexual development.,  Eds. Ho K.Y., Werther G.A., Cowel C.J., Harwood Academic Publishers. pp 3-28.
18. Lobie, P.E., Garcia-Aragon, J., Lincoln, D.T., Barnard, R., Wilcox, J.N., Waters, M.J. (1993) Localization and ontogeny of growth hormone receptor gene expression in the central nervous system. Dev. Brain. Res. 74: 225-233
19. Lobie, P.E., Garcia-Aragon, J., Waters, M.J. (1993) Prolactin receptor expression in the gastrointestinal tract: characterization of the prolactin receptor in gastric mucosa. J. Endocrinol. 139: 371-382
20. Norstedt, G., Enberg, B., Francis, S.M., Lobie, P.E. (1993) The growth hormone receptor during development. Reprod. Dom. Anim. 28: 145-153
21. Mertani HC, Lobie PE, Waters MJ, Morel G (1994) Internalization process of 125I-bovine growth hormone in rat liver. I.C.E.M 13: 327-328
22. Lobie, P.E., Mertani, H., Morel, G., Morales-Bustos, O., Norstedt, G., Waters, M.J. (1994) Receptor mediated nuclear translocation of growth hormone. J. Biol. Chem. 269: 21330- 21339
23. Norstedt, G., Enberg, B., Francis, S., Hansson, A., Hulthen, A., Lobie, P.E., Sliva, D., Wood, T.J.J., Billestrup, N. (1994) Cell transfection as a tool to study growth hormone action. Proc. Soc. Exp. Biol. Med. 206: 181-184
24. Waters, M.J., Rowlinson, S.W., Clarkson, R.W., Chen, C.M., Lobie, P.E.,  Norstedt, G., Mertani, H., Morel, G., Brinkworth, R., Wells, C.A., Bastiras, S., Robins, AR, Muscat, G.E., Barnard, R.T. (1994) Signal transduction by the growth hormone receptor. Proc. Soc. Exp. Biol. Med. 206: 216-220
25. Norstedt, G., Enberg, B., Francis, S.M., Lobie, P.E. (1994) The growth hormone receptor: Tissue distribution and mechanism of action. In Sizonenko PC, Aubert ML, Vassali J-D (Eds) Frontiers in Endocrinology; Developmental Endocrinology. Ares Serono Symposia. Rome. pp 219-229.
26. Sliva, D., Wood, T.J.J., Schindler, C., Lobie, P.E., Norstedt, G. (1994) Growth hormone specifically regulates serine protease inhibitor gene transcription via a gamma activated sequence like DNA element. J. Biol. Chem. 269: 26208- 26214.
27. Lobie, P.E., Wood, T.J.J., Sliva, D., Billestrup, N., Waters, M.J., Enberg, B., Norstedt, G. (1994) The cellular mechanism of growth hormone signal transduction. Acta Paed. Scand. 406: 39-46
28. Lobie, P.E., Wood, T.J.J., Chen, C.M., Waters, M.J., Norstedt, G (1994) Nuclear translocation and anchorage of the growth hormone receptor. J. Biol. Chem. 269: 31735- 31746.
29. Lobie PE, Morel G, Mertani H, Morales-Bustos O, Wood TJJ, Waters MJ, Norstedt G (1995) The growth hormone receptor, growth hormone and the nucleus. Endo. Metab. 2: 61-72
30. Wood TJJ, Sliva D, Lobie PE, Pircher T, Wakao H, Gouilleux F, Gustafsson J-Å, Groner B, Norstedt G, Haldosen L-A (1995) Mediation of growth hormone signal transduction by STAT 5 / mammary gland factor. J. Biol. Chem. 270: 9448-9453
31. Parini P, Angelin B, Lobie PE, Norstedt G, Rudling M (1995) Growth hormone specifically stimulates low density lipoprotein receptor expression in cultured human hepatoma cells. Endocrinology 136: 3767-3773
32. Lobie PE, Allevato G, Nielsen JH, Norstedt G, Billestrup N (1995) Requirement of tyrosine residues 333 and 338 of the growth hormone receptor for selected GH stimulated function. J. Biol. Chem. 270: 21745-21750.
33. Oinonen T, Mode A, Lobie PE, Lindros KO (1996) Zonation of cytochrome P450 enzyme expression  in  rat liver : isozyme-specific regulation by pituitary dependent hormones. Biochem Pharmacol.  51: 1379-1387.
34. Lobie, PE, Roncin, B, Silvennoinen O, Haldosen LA, Norstedt G, Morel G (1996) Constitutive nuclear localization of Janus Kinases 1 and 2. Endocrinology 137: 4037-4045.
35. Lobie PE (1997) Light microscopic visualization of polypeptide ligand receptors. In Morel G (Ed.) Visualization of receptors by light and electron microscopy. CRC Press. pp 181- 196.
36. Wood TJJ, Sliva D, Lobie PE, Gouilleux F, Mui A, Groner B, Norstedt G, Haldosen L-A (1997) Specificity of transcriptional enhancement via the STAT responsive element from the serine protease inhibitor 2.1 promoter. Mol. Cell. Endocrinol. 130: 69-81.
37. Goh ELK, Pircher TJ, Wood TJJ, Norstedt G, Graichen R, Lobie PE (1997) Growth hormone induced re-organization of the actin cytoskeleton is not required for STAT5 mediated transcription. Endocrinology 139: 3207-3215.
38. Lobie PE, Waters MJ (1997) Growth hormone regulation of submandibular gland structure and function in the GH deficient rat: upregulation of haptocorrin. J. Endocrinol. 154 : 459-466.
39. Liu N, Mertani HC, Norstedt G, Törnell J, Lobie PE (1997) Mode of the autocrine/ paracrine mechanism of growth hormone action. Exp. Cell Res. 237: 196-206
40. Zhu T, Goh ELK, Lobie PE (1998) Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. FAK is not required for STAT mediated transcription. J. Biol. Chem. 273: 10682-10689.
41. Mertani HC, Garcia-Cabellero T, Lambert A, Gerard F, Pelaye C, Boutin JM, Vonderhaar BK, Waters MJ, Lobie PE, Morel G (1998) Cellular expression of growth hormone and prolactin receptors in human breast disorders. Int. J. Cancer 79: 202-211.
42. Morel G, Berger M, Ronsin B, Recher S, Ricard-Blum S, Mertani HC, Lobie PE (1998) In situ reverse transcription-polymerase chain reaction (in situ RT-PCR): Applications for light and electron microscopies. Biol. Cell. 90: 137-154.
43. Goh ELK, Pircher TJ, Lobie PE (1998) Growth hormone promotion of tubulin polymerization stabilizes the microtubule network and protects against colchicine induced apoptosis. Endocrinology 139: 4364-4372.
44. Zhu T, Goh ELK, LeRoith D, Lobie PE (1998) Growth hormone stimulates the formation of a multiprotein signalling complex involving p130Cas and CrkII. Resultant activation of JNK/SAPK. J. Biol. Chem. 273: 33864-33875.
45. Lobie PE, Sadir R, Graichen R, Mertani HC, Morel G (1999) Caveolar internalization of growth hormone. Exp. Cell. Res. 246: 47-55.
46. Mertani HC, Morel G, Lobie PE (1999) Cytoplasmic and nuclear cytokine receptor complexes. Vitam. Horm. 57: 79-121.
47. Lobie PE (1999) Signal transduction through the growth hormone receptor. Chapter 2 in Bengtsson BA (ed) Growth Hormone. in Melmed S (ed) Endocrine Update Book Series. Kluwer Academic Publishers. pp17-35.
48. Kaulsay KK, Mertani HC, Tornell J, Morel G, Lee KO, Lobie PE (1999) Autocrine stimulation of human mammary carcinoma cell proliferation by human growth hormone. Exp. Cell Res. 250: 35-50
49. Waters MJ, Shang CA, Behncken SN, Tam SP, Li H, Shen B, Lobie PE (1999) Growth hormone as a cytokine. Clin. Exp. Pharmacol. Physiol. 26:760-764
50. Zhu T, Lobie PE (2000) Janus kinase 2 dependent stimulation of p38 MAP kinase activity by growth hormone: Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis. J. Biol. Chem. 275: 2103-2114.

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