Prof. Panagiotidis Mihalis

Prof. Panagiotidis Mihalis

Professor of Nutrition & Toxicology

Heriot Watt University, School of Life Sciences
John Muir Building, Riccarton Campus, Edinburgh, United Kingdom, EH14 4AS

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Mihalis currently holds a Professor of Nutrition & Toxicology faculty position while at the same time serves as a Department Head of Human Health at the School of Life Sciences, Heriot-Watt University, UK. He has research expertise in the areas of molecular toxicology, molecular & biochemical nutrition and human carcinogenesis as evident by a number of peer-reviewed publications. In addition, he serves as (1) an Editor-in-Chief for the American Journal of Food & Nutrition, (2) an Associate Editor for Biochemical Technology and Pharmacology & Therapeutics and (3) an Editorial Board Member for Mutation Research-Genetic Toxicology & Environmental Mutagenesis, Cancer Letters, International Journal of Experimental Pathology, Toxicology Mechanisms & Methods and World Journal of Respirology. Finally, he is (i) an Active Member of the Education Quality Accreditation Commission, (ii) a Scientific Advisory Board Member for the International Institute of Anticancer Research and also has been (iii) a Marilyn Gentry Fellow of the American Institute for Cancer Research & World Cancer Research Fund.

Mihalis is the Director of the Human Nutrition & Molecular Toxicology Group which conducts research on (1) molecular mechanisms underlying disease pathophysiology, (2) molecular therapeutics & biomarker development and (3) nutrition & disease prevention. Specifically, the group is investigating into the role of apoptosis and epigenetics as key cellular pathways being deregulated as part of the pathophysiology in a wide number of human diseases. In addition, the group utilizes genomic approaches in identifying gene targets with the potential to serve as biomarkers of therapeutic outcome. Finally, the group investigates how natural products exert a wide range of bioactive properties and thus are considered to be of great benefit in health and disease. To these ends, we are seeking industrial and academic partners for collaborative projects aiming towards major funding opportunities.

Academic positions:

1. 1999-2004: DOCTOR OF PHILOSOPHY (PhD) IN TOXICOLOGY; School of Pharmacy, University of Colorado, Denver, Colorado, USA
2. 1994-1996: MASTER OF SCIENCE (MSc) BY RESEARCH; Department of Molecular & Cell Biology, University of Aberdeen, Scotland, UK
3. 1993-1994: POSTGRADUATE DIPLOMA (PGd) IN HUMAN NUTRITION & METABOLISM; Department of Human Nutrition, University of Aberdeen, Scotland, UK
4. 1992-1993: POSTGRADUATE DIPLOMA (PGd) IN MEDICAL & MOLECULAR GENETICS Department of Molecular & Cell Biology, University of Aberdeen, Scotland, UK
5. 1988-1992: BACHELOR OF SCIENCE (BSc) IN PURE SCIENCE; Department of Molecular & Cell Biology, University of Aberdeen, Scotland, UK

Professional Experience
1. 10/2013-Present: HEAD OF DEPARTMENT (HUMAN HEALTH); School of Life Sciences, Heriot Watt University, Edinburgh, Scotland, UK
2. 01/2013-Present: PROFESSOR (PERSONAL CHAIR IN NUTRITION & TOXICOLOGY); School of Life Sciences, Heriot Watt University, Edinburgh, Scotland, UK
3. 01/2012-12/2012: ASSISTANT PROFESSOR (MOLECULAR PATHOLOGY) Laboratory of Pathological Anatomy, University of Ioannina, Medical School, Ioannina, GREECE
4. 11/2011-01/2012: ASSOCIATE PROFESSOR (HUMAN NUTRITION); School of Biosciences, University of Nottingham, Malaysia Campus, MALAYSIA
School of Community Health Sciences, University of Nevada-Reno, Nevada, USA
6. 02/2010-02/2011: INSTRUCTOR; Department of Natural Sciences & Mathematics, Undergraduate Programs in Pharmacy & Nutrition, American University of Athens, Athens, GREECE
7. 09/2009-09/2010: VISITING PROFESSOR (HUMAN NUTRITION); Biology Unit, University of Thessaly-Volos, Volos, GREECE
8. 07/2007-07/2009: ASSISTANT PROFESSOR (ENVIRONMENTAL & OCCUPATIONAL HEALTH); School of Community Health Sciences, University of Nevada-Reno, Nevada, USA
9. 08/2006-07/2007: RESEARCH ASSISTANT PROFESSOR (HUMAN NUTRITION) Department of Nutrition, University of North Carolina-Chapel Hill, North Carolina, USA
10. 07/2004-07/2006: IRTA POSTDOCTORAL FELLOW; Laboratory of Signal Transduction, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, North Carolina, USA
11. 06/2001-06/2004: PREDOCTORAL FELLOW; Department of Pediatrics, National Jewish Medical & Research Center, Denver, Colorado, USA
12. 09/1999-05/2001: TEACHING ASSISTANT; Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado, USA
13. 08/1998-08/1999: VISITING RESEARCH ASSOCIATE; Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado, USA
14. 02/1996-07/1998: RESEARCH ASSOCIATE; Laboratory of Biological Chemistry, University of Ioannina Medical School, Ioannina, GREECE
15. 10/1994-07/1995: VISITING RESEARCH ASSOCIATE; Laboratory of DNA Repair, Institute of Biology, National Center for Scientific Research “DEMOKRITOS”, Athens, GREECE

Awards & Fellowships
1. Molecular Cancer Research Association in Turkey Award (co-author), EACR-Anticancer Agents Research Congress, 2011, Antalya, TURKEY
2. American Institute for Cancer Research (AICR) Travel Fellowship, AICR/WCRF International Research Conference on Food, Nutrition and Cancer, 2006, Washington, D.C, USA
3. American Society for Biochemistry & Molecular Biology (ASBMB) Travel Fellowship, Experimental Biology Meeting, 2006, San Francisco, USA
4. NIH/NIEHS Postdoctoral Intramural Research Training Award (IRTA), Laboratory of Signal Transduction, National Institute of Environmental Health Sciences (NIEHS/NIH), 2004-2006, Research Triangle Park, USA
5. European Hematology Association (EHA) Travel Fellowship, First Practical Training Course on Apoptosis, 1997, Saclay, FRANCE
6. NATO/FEBS/UNESCO Travel Fellowship, NATO Advanced Institute Course in Free Radicals, Oxidative Stress and Antioxidants: Pathological and Physiological Significance, 1997, Antalya, TURKEY
7. NATO/FEBS Advanced Study Institute Travel Fellowship, International Summer School Course on “Molecular Mechanisms of Signaling and Targeting”, 1996, Island of Spetses, GREECE

Professional Service
1. Scientific Book Proposal Reviewer(2013), Academic Press, Elsevier, UK
2. Grant Assessor (2013), Wellcome Trust / DBT India Alliance Biomedical Research Fellowship Program for India
3. Grant Assessor (2013), Wellcome Trust / Massachusetts Institute of Technology Postdoctoral Fellowship Program, UK
4. Grant Assessor (2013), French National Alliance for Life and Health Sciences (AVIESAN) jointly with the FrenchNational Cancer the French NationalAlliance Institute (INCa), FRANCE
5. Reviewer (2012), Ministry of Education, State Scholarships Foundation, Athens, GREECE
6. Reviewer (2010-2013), “Travel Awards”, Society for Free Radical Biology & Medicine (SFRBM), USA
7. Study Section Panel (2010-2012), Ministry of Development, General Secretariat for Research & Technology; “Supporting New Enterprises in Research & Technological Development with Emphasis on Agriculture, Fisheries, Foods & Biotechnology”, Athens, GREECE
8. Grant Assessor (2011), Ministry of Development, General Secretariat for Research & Technology; Committee in “Supporting New Enterprises in Research & Technological Development”, Athens, GREECE
9. Grant Assessor (2007), Ministry of Development, General Secretariat for Research & Technology, Athens, GREECE
10. Reviewer (2007), “Best Postdoctoral Paper Award”, Society of Toxicology, USA
11. Reviewer (2006), Student Academy of Science State Competition, North Carolina, USA
12. Reviewer(2005); FARE Travel Award; NIH Study Section: Free Radicals & Oxidative Stress, USA

Professional Affiliations
1. Active Member of the European Association for Cancer Research (EACR) (2010 to present)
2. Active Member of the Education Quality Accreditation Commission (EQAC) (2010 to present)

3. Active Member of the Society for Free Radical Biology & Medicine (SFRBM), (2007-2010)
4. Active Member of the American Association for Cancer Research (AACR). Member of the “Chemistry in Cancer Research Working Group”, “Tumor Microenvironment Working Group” and “Cancer Immunology Working Group”, (2007-2010)
5. Active Member of the Society of Toxicology (SOT), (2007-2010)
6. Co-chairof the Society of Toxicology Postdoctoral Assembly Committee, (2006-2007)

Research interests:

Biomarkers of nutrition intervention, Natural products and disease prevention, Phytochemical micronutrients with epigenetic properties, Natural products as adjuvant therapy in cancer

Any other information:

Peer-Reviewed Journals
1. Panayiotidis M, Collins AR. Ex vivo assessment of lymphocyte antioxidant status using the comet assay. Free Rad Res 27(5): 533-537, 1997
2. Collins AR, Dusinka M, Franklin M, Somorovska M, Petrovska H, Duthie S, Fillion L, Panayiotidis M, Raslova K, Vaughan N. The comet assay in human biomonitoring studies: reliability, validation and applications. Environ Mol Mutagen 30(2): 139-146, 1997
3. Panayiotidis M, Tsolas O, Galaris D. Glucose oxidase produced H2O2 induces Ca2+-dependent DNA damage in human peripheral blood lymphocytes. Free Rad Biol Med 26(5-6): 548-556, 1999
4. Panayiotidis MI, Rancourt RC, Allen CB, Riddle SR, Schneider BK, Ahmad S, White CW. Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cells. Antiox Redox Signal 6(1):129-136, 2004
5. Panayiotidis MI, Stabler SP, Allen RH, Ahmad A, White CW. Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells. Chem Biol Interact 147(1): 87-97, 2004
6. PanayiotidisMI, StablerSP, AhmadA, Pappa A, Legros LH Jr, Hernandez-SaavedraD, Schneider BK, AllenRH, Vasiliou V, McCordJM, KotbM, WhiteCW. Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia. Free Rad Biol Med 40(2): 348-358, 2006
7. Panayiotidis MI, Bortner CD, Cidlowski JA. On the mechanism of ionic regulation of apoptosis: Would the Na+/K+-ATPase please stand up? Acta Physiol (Oxf) 187(1-2): 205-215, 2006
8. Panayiotidis MI, Rancourt RC, Pappa A, White CW. Effect of cell cycle growth arrest on global DNA methylation status in human lung epithelial-like (A549) cells. In Vivo 20(6B): 861-865, 2006
9. Franco R, Schoneveld OJ, Pappa A, Panayiotidis MI. Thecentral role of glutathione in the pathophysiology of human diseases.  Arch Physiol Biochem 113(4-5): 234-258, 2007
10. Franco R, Panayiotidis MI, Cidlowski JA. Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation. J Biol Chem282(42): 30452-30465, 2007
11. Pappa A, Franco R, Schoneveld, O Galanis A, Sandaltzopoulos R, Panayiotidis MI. Sulfur-containing compounds in protecting against oxidant-mediated lung diseases. Curr Med Chem 14(24): 2590-2596, 2007
12. Franco R, Panayiotidis MI, de la Paz LD. Autocrine signaling involved in cell volume regulation: the role of released transmitters and plasma membrane receptors. J Cell Physiol 216(1): 14-28, 2008
13. Franco R, Schoneveld O, Georgakilas AG,Panayiotidis MI. Oxidative Stress, DNA methylation and carcinogenesis. Cancer Lett 266(1): 6-11, 2008
14. Peddi P, Francisco DC, Cecil AM, Hair JM, Panayiotidis MI, Georgakilas AG. Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKCs deficiency. Cancer Lett 269(1): 174-183, 2008
15. Panayiotidis MI. Reactive oxygen species (ROS) in multistage carcinogenesis. Cancer Lett 266(1): 3-5, 2008
16. Holt SM, Scemama JL, Panayiotidis MI, Georgakilas AG. Compromised repair of clustered DNA damage in the human acute lymphoblastic leukemia MSH2-deficient NALM-6 cells. Mutat Res 674 (1-2): 123-130, 2009
17. Nowsheen S, Wukovich RL, Aziz K, Kalogerinis PT, Richardson CC, Panayiotidis MI, Bonner WM, Sedelnikova OA, Georgakilas AG. Accumulation of oxidatively-induced clustered DNA lesions in human tumor tissues. Mutat Res 674 (1-2): 131-136, 2009
18. Panayiotidis MI, Stabler SP, Allen RH, Pappa A, White CW. Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. Mutat Res 674 (1-2): 23-30, 2009
19. Franco R, Sánchez-Olea R, Reyes-Reyes EM, Panayiotidis MI. Environmental toxicity, oxidative stress and apoptosis: ménage à Trois, Mutat Res 674 (1-2): 3-22, 2009
20. Franco R, Panayiotidis MI. Environmental toxicity, oxidative stress, human disease and the “black box” of their synergism: how much have we revealed? Mutat Res 674 (1-2): 1-2, 2009
21. Georgakilas AG, Aziz K, Ziech D, Georgakila S, Panayiotidis MI. BRCA1 involvement in toxicological responses and human cancer etiology. Toxicol Lett 188(2): 77-83, 2009
22. Peddi P, Loftin CW, Dickey JS, Hair JM, Burns KJ, Aziz K, Francisco DC, Panayiotidis MI, Sedelnikova OA, Bonner WM, Winters TA, Georgakilas AG. DNA-PKCs deficiency leads to persistence of oxidativelyinduced DNA lesions in human tumor cells. Free Rad Biol Med, 48(10): 1435-1443, 2010
23. Georgakilas AG, Mosley WG, Georgakila S, Ziech D,Panayiotidis MI. Viral-induced human carcinogenesis: an oxidative stress perspective. Mol Biosyst, 6(7): 1162-1172, 2010
24. Panayiotidis MI, Franco R, Bortner CD, Cidlowski JA. Ouabain-induced perturbations in intracellular ionic homeostasis regulate death-receptor-mediated apoptosis. Apoptosis, 15(7): 834-849, 2010
25. Ziech D, Franco R, Pappa A, Malamou-Mitsi V, Georgakila S, Georgakilas AG, Panayiotidis MI. The role of epigenetics in environmental and occupational carcinogenesis. Chem Biol Interact, 188(2): 340-349, 2010
26. Ziech D, Franco R, Georgakilas AG, Georgakila S, Malamou-Mitsi V, Schoneveld O, Pappa A,Panayiotidis MI. The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development. Chem Biol Interact, 188(2): 334-339, 2010
27. Franco R, Panayiotidis MI. Cell death or survival: The double edge sword of environmental and occupational toxicity. Chem Biol Interact, 188(2): 265-266, 2010
28. Franco R, Li S, Rodriguez-Rocha H, Burns M, Panayiotidis MI. Molecular mechanisms of pesticide-induced neurotoxicity: Relevance to Parkinson’s disease. Chem Biol Interact, 188(2): 289-300, 2010
29. Ziech D, Franco R, Pappa A, Panayiodtidis MI. Reactive oxygen species (ROS)-induced genetic and epigenetic alterations in human carcinogenesis. Mutat Res, 711(1-2): 167-173, 2011
30. Voulgaridou GP, Anestopoulos I, Franco R, Panayiotidis MI, Pappa A. DNA damage induced by endogenous aldehydes: current state of knowledge. Mutat Res, 711(1-2): 13-27, 2011
31. Rodriguez-Rocha H, Garcia-Garcia A, Panayiotidis MI, Franco R. DNA damage and autophagy. Mutat Res, 711(1-2): 158-166, 2011
32. Karapetsas A, Giannakakis A, Pavlaki M, Panayiotidis M, Sandaltzopoulos R, Galanis A. Biochemical and molecular analysis of the interaction between ERK2 MAP Kinase and hypoxia inducible factor-1?. Int J Biochem Cell Biol, 43(11): 1582-1590, 2011
33. Nowsheen S, Aziz K, Panayiotidis MI, Georgakilas AG. Molecular markers for cancer prognosis and treatment: Have we struck gold? Cancer Lett, 327(1-2): 142-152, 2012
34. Hanafi R, Anestopoulos I, Voulgaridou GP, Franco R, Georgakilas AG, Ziech D, Malamou-Mitsi V, Pappa A, Panayiotidis MI. Oxidative stress based-biomarkers in oral carcinogenesis: how far have we gone?Curr Mol Med, 12(6): 698-703, 2012
35. Garcia-Garcia A,Rodriguez-Rocha H, Madayiputhiya N, Panayiotidis MI, Franco R. Biomarkers of protein oxidation in human disease. Curr Mol Med, 12(6): 681-697, 2012
36. Georgakilas AG, Panayiotidis MI. Editorial: biomarkers of oxidative stress and cancer: from chemistry, biology to clinical applications and personalized therapy. Curr Mol Med, 12(6): 653-654, 2012
37. Ziech D, Anestopoulos I, Hanafi R, Voulgaridou GP, Franco R, Georgakilas AG, Pappa A, Panayiotidis MI. Pleiotrophic effects of natural products in ROS-induced carcinogenesis: The role of plant-derived natural products in oral cancer chemoprevention. Cancer Lett, 327(1-2): 16-25, 2012
38. Voulgaridou GP, Mantso T, Chlichlia K, Panayiotidis MI, Pappa A. Efficient E. coli expression strategies for production of soluble human crystallin ALDH3A1. PLOS One, 8(2): e56582, 2013
39. Anestopoulos I, Kavo A, Tentes I, Kortsaris A, Panayiotidis MI, Lazou A, Pappa A. Silibinin protects cardiac myocytes from oxidative stress and inhibits cardiac hypertrophy in vitro: Potential mechanisms. J Nutr Biochem, 24(3): 586-594, 2013
40. Panayiotidis MI. Featuring the special issue editor. Cancer Lett, 342: 167, 2014
41. Panayiotidis MI. Cancer epigenetics as biomarkers of clinical significance. Cancer Lett, 342: 168-169, 2014
42. Hatzi VI, Laskaratou DA, Mavragani IV, Nikitaki Z, Mangelis A, Panayiotidis MI, Pantelias GE, Terzoudi GI, Georgakilas AG. Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology. Cancer Lett, 2014 (in press) [Epub ahead of print]

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