Prof. Boucher Philippe

Prof. Boucher Philippe

Professor of Physiology

Facult�© de Pharmacie, University of Strasbourg
74, route du Rhin, Illkirch, France, 67401

plus Speciality




1. 2008-Present: Full Professor; University of Strasbourg
2. 2003-2008: Assistant Professor (Maitre de Conférences); University of Strasbourg
3. 2000: Habilitation (HDR); University of Lyon
4. 1999: Ph.D, Laboratory of Pr J.J. Vallon, Faculty of Pharmacy; University of Lyon
5. 1993: Clinical Pharmacology degree (D.E.S. de Biologie Médicale); University of Lyon
6. 1991: Master in Neurosciences (D.E.A. de Neurosciences); University of Lyon
7. 1983-1989: Pharm.D (Diplôme de Pharmacien); University of Lyon

Post-Doctoral Training:

1. 2000-2003: University of Texas Southwestern Medical Center at Dallas

Academic positions:

Hospital Degrees and Diplomas:

1. 1993-2000: Clinical Assistant (Assistant Spécialiste des Hôpitaux); CHU de Lyon
2. 1990-1993: Residency (Interne des Hôpitaux option Biologie Médicale); CHU de Lyon
3. 1991-1992: Research training year (Année recherche); CHU de Lyon
4. 1986-1988: Rotating Student (Externe des Hôpitaux); CHU de Lyon

University Teaching Responsibilities:


2008- present Physiology (undergraduate students) University of Strasbourg: 190h/year


2003-present Master students (20), PhD students (5), Post doc fellow (5) founded by: Fondation
pour la Recherche Médicale (FRM), Région Alsace, Société Française d’athérosclérose, Agence

Nationale de la Recherche (ANR), CNRS, University of


1. 2003-2005: SUPPORTED BY (190 K€): Fondation de France, University of Strasbourg (Young
investigator starting grant), CNRS, French ministry of research, Fondation pour la
recherche médicale.
2. 2005-2008: SUPPORTED BY (240 K€): Agence Nationale de la Recherche (ANR). Programme
“Cardiovasculaire, obésité, et diabète”.
3. 2006-2009: SUPPORTED BY (180 K€): Agence Nationale de la Recherche (ANR). Programme
“Physiopathologie des maladies humaines”.
4. 2008-2009: SUPPORTED BY (75 K€): “Région Alsace”.
5. 2009-2013: SUPPORTED BY (594 K€): Agence Nationale de la Recherche (ANR). Programme “ANR
6. 2010-2013: SUPPORTED BY (100 K€): Fondation de France
7. 2011-2014: SUPPORTED BY (300 K€): Fondation Recherche Médicale
8. 2012-2016: SUPPORTED BY (430 K€): “ANR Blanc SVSE 1 - Physiologie, physiopathologie, santé
publique”, Co-PI : Dr M.Ch. Bouton, INSERM, Paris

Scientific Prizes and Honours:

1999: “French Society for Endocrinology” Award, 1999 « InnovaLyon » Award, 2003 American

Society for Pharmacology and Experimental Therapeutics (ASPET)Young Scientist Travel Award,

2003 French National Academy of Medicine “Eloi Collery” Award, 2003 Young Scientist “Jean

Valade” Award 2003.

Research interests:

Physiology, Physiopathology of atherosclerosis, Vascular remodeling, Cell signaling and heart failure

Any other information:

Peer-Reviewed Research

1. E. Woldt, J. Terrand, M. Mlih, R. L. Matz, V. Bruban, S. Foppolo, Z. El Asmar, M. E. Cholet, E. Ninio, A. Bednarczyk, D. Thiersé, C. Schaeffer, A. Van Dorsselaer, C. Boudier, W. Wahli, P. Chambon, D. Metzger, J. Herz, P. Boucher. The nuclear hormone receptor PPARg counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells. Nature Commun., 2012 Sep 25;3:1077.
2. Woldt E, Matz RL, Terrand J, Mlih M, Gracia C, Foppolo S, Martin S, Bruban V, Ji J, Velot E, Herz J, Boucher P. Differential signaling by adaptor molecules LRP1-SHCA regulates adipogenesis by the insulin-like growth factor-1 receptor. J Biol Chem. 2011 May 13;286(19):16775-82.
3. Ph. Boucher and Joachim Herz. Signaling through LRP1: Protection from atherosclerosis and beyond. Invited review Biochem Pharmacol. 2011 Jan 1;81(1):1-5.
4. Zhou L., Takayama Y., Boucher Ph., Tallquist M., Herz J. LRP1 Regulates Architecture of the Vascular Wall by Controlling PDGFRβ-Dependent Phosphatidylinositol 3-Kinase Activation. PLoS One. 2009 Sep 9;4(9):e6922.
5. Terrand J, Bruban V, Zhou L, Gong W, El Asmar Z, May P, Zurhove K, Haffner P, Philippe C, Woldt E, Matz RL, Gracia C, Metzger D, Auwerx J, Herz J, Boucher Ph. LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling. J Biol Chem. 2009 Jan 2;284(1):381-8.
6. Ph. Boucher, W. Li, R. Matz-Westphal, Y. Takayama, J. Auwerx, R. G. W. Anderson, J. Herz LRP1 functions as an atheroprotective integrator of TGFb and PDGF signals in the vascular wall. PLoS ONE. 2007 May 16;2:e448.
7. P. May, E. Woldt, R. L. Matz, Ph. Boucher. The LDL Receptor Related Protein (LRP) protein family Ann Med. 2007;39(3):219-28.
8. Ph. Boucher, M. Gotthardt. LRP and PDGF Signaling: A Pathway to Atherosclerosis. Trends Cardiovasc Med. 2004 Feb;14(2):55-60.
9. Cachefo A., Boucher Ph., Bouletreau P., Vidon C., Diraison F., Beylot M., Chambrier C. Hepatic lipogenesis and cholesterol synthesis in patients with home parenteral nutrition J. Lip Res., 2003 Jul; 44(7): 1349-54.
10. Ph. Boucher, M. Gotthardt, W. Li, R. G. W. Anderson, and J. Herz. LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis. Science, Volume 300, Number 5617, Issue of 11 Apr 2003, pp. 329-332.
11. Ph. Boucher, P Ducluzeau, P. Davelu, F. Andreelli, P. Vallier, JP Riou, M. Laville and H. Vidal. Expression and Regulation by Insulin of Low Density Lipoprotein Receptor-Related Protein (LRP) mRNA in Human Skeletal Muscle. Biochim Biophys Acta. 2002 Dec 12;1588(3):226.
12. JC Picaud, Ph Boucher, A Lapillonne, M Berthouze, E Delvin, G Boehm, O Claris, S Laborie, MD, B Reygrobellet, H Lapillonne, F Glorieux, B Salle. Influence of dietary cholesterol on vitamin D metabolism in formula-fed preterm neonates. J Pediatr Gastroenterol Nutr. 2002, 35:180-184.
13. Ph. Boucher, P. Liu, M. Gotthardt, T. Hiesberger, R. G. W. Anderson, and J. Herz. PDGF mediates tyrosine phosphorylation of the cytoplasmic domain of the LDL receptor-related protein (LRP) in caveolae. J.Biol.Chem., 2002;277 15507-15513.
14. Miachon S, Augier S, Jouvenet M, Boucher Ph, Vallon J.J. Nutritional parameters modify muricidal behavior of male wistar rats. Preventive effects of endozepine receptor ligands. Life Sci., 2001 Oct 26; 69(23):2745-57.
15. Cachefo A, Boucher Ph, Vidon C, Dusserre E, Diraison F, Beylot M. Hepatic lipogenesis and
cholesterol synthesis in hyperthyroid patients. J Clin Endocrinol Metab., 2001 Nov; 86(11): 5353-7.
16. C. Vidon, Ph. Boucher, A. Cachefo, O. Peroni, F. Diraison and M. Beylot. Effects of isoenergetic highcarbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key regulatory genes of cholesterol metabolism. Am J Clin Nutr. 2001 May; 73(5): 878-884
17. E. Serre, Ph. Boucher. Du gene à la clinique: la Pharmacogénétique. La revue du Biopathologiste, 2001.
18. Ph. Boucher, E. Seree, C. Vidon, A. Cachefo de Souza, P.H. Villard, R. Chambon, Y. Barra, B. Lacarelle, and J.J. Vallon. Dietary lipids affect human ethanol-inducible CYP2E1 gene expression in vivo, in mononuclear cells. Life Sci., 2000, 67, 1307-1316.
19. L. Sebbag, Ph. Boucher, P. Boissonnat, P. Davelu, G. Champsaur, J. Ninet, G. Dureau, J.F. Obadia, J.J. Vallon and J. Delaye. Thiopurine S-methyltransferase gene polymorphism is predictive of azathioprine induced myelosuppression in heart transplant recipients. Transplantation, 2000, 69 (7), 1524-1527.
20. Ph. Boucher, J. Greffe, J.J. Vallon. Intérêts et applications de la Pharmacogénétique en Biologie Clinique. Cahier de Formation Biologie Médicale, Tome II, N°18, janvier 2000, 111-124.
21. Ph. Boucher, J.J. Vallon. Apports de la Pharmacogénétique à la Chimiothérapie Anticancéreuse. Métastases, 1999, 2, 2-10.
22. Ph. Boucher, M. de Lorgeril, P. Salen, P. Crozier, J. Delaye, J.J. Vallon, A. Geyssant, R. Dante. Effect of dietary cholesterol on LDL receptors, HMG CoA reductase and LDL receptor-related protein (LRP) expression in healthy humans. Lipids, 1998, Dec;33(12):1177-86.
23. M. de Lorgeril, P. Salen, J.L. Martin, I. Monjaud, Ph. Boucher, N. Mamelle. Mediterranean dietary pattern in a randomized trial. Prolonged survival and possible reduced cancer rate. Arch. Intern. Med. 1998, 158, 1181-1187.
24. Ph. Boucher, M. Accominotti, J.J. Vallon. Arsenic speciation by ion-pair reversed phase liquid chromatography with coupled amperometric and U.V. detection. J. Chromatogr. Sci. 1996, 34, 1-4.
25. Ph. Boucher, H. Lejeune, MC. Pinatel, Y. Gille. Spermoculture : Improvement of the Bacteriological Quality of samples in Direct Verbal Counselling Before Semen Collection.
Fertil. Steril., 1995, 64, 3, 657-660.
26. M.C. Pinatel, Ph. Boucher, Y. Gille, F. Pinatel. Proposition d'un protocole de  prélèvements pour spermocultures. Andrologie. 1994, 2, 228-233.
27. G. Antoniotti, Ph. Boucher, V. Buisson, J.F. Chaulet. Intérêt de la technique d'immunofixat

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